In the Next Generation episode "Cause and Effect", in the teaser - the Enterprise D explodes. Poof! Gone.
The episode features a recurring time loop and we see the ship reconstitued, and exploded multiple times, due to a collision. Finally, the ship is saved by "decompressing the main shuttlebay"... note the shuttles within.
So how do you make a nacelle explode? Build a nacelle that you are willing to explode. And how do you make the main shuttlebay doors open? Build a shuttlebay with doors that open.
I was able to obtain the nacelle model in the 2006 Christie's auction, and the shuttlebay model later from the It's a Wrap auctions. They are great companions... but rather large. The nacelle is about 8 feet long. The first pictures shows it in the shipping crate, and the second installed at my place.
The hanger bay was a real treat, one of the few models available from It's A Wrap. The doors work, like a roll-top desk. You can see the wood sides in this view... the model was carefully cropped on-screen to avoid that! I've since added two shuttles.